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KMID : 0359320030430030463
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Korean Journal of Veterinary Research
2003 Volume.43 No. 3 p.463 ~ p.469
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Porcine Circovirus Infection in Weaned Pigs with Postweaning Multisystemic Wasting Syndrome in Korea
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Kim, Jae-hoon/김재훈
Roh, In-soon/Sohn, Hyun-joo/Jean, Young-hwa/Hwang, Eui-kyung/Yoon, Kyoung-jin/노인순/손현주/진영화/황의경/윤경진
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Abstract
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Eight nursery to grower pigs exhibiting weight loss and sudden death were diagnosed as postweaning multisystemic wasting syndrome (PMWS) based on the results of gross findings, histopathology, immunohistochemistry, fluorescent antibody test, virus isolation, PCR, serology, and electron microscopy. Grossly, the pigs had a rough hair coats and were severely emaciated. And most lymph nodes were pale and enlarged. Lungs were not fully collapsed and exhibited 10 to 40％ pale red cranioventral consolidation. Histopathologically, typical lymphohistiocytic interstitial to bronchointerstitial pneumonia, chronic lymphadenitis, severe lymphoid depletion, and basophilic intracytoplasmic inclusions were noted in the most lymphoid tissues, Porcine cirrcovirus particles were observed in the inguinal lymph node of the pigs by electron microscopy. Porcine circovirus type 2 (PCV2) antigens or viral DNAs were detected in the lesions of all pigs using immunohistochemistry or PCR. Two PCV2 were isolated from a homogenate of pooled lung and lymph node in 2 of the 5 pigs. Additionally, antigens of porcine reproductive and respiratory syndrome virus (PRRSV) and Hemophilus (H.) parasuis were also detected by immunofluorescent antibody test. Serologically, 55％ of randomly selected sows and fattening pigs was serum antibody positive to PCV2 by an indirect fluorescent antibody (IFA) test and approximately 18％ of animals in the here were serologically positive by the ELISA kit for PRRSV. To our knowledge, this is the first report of PMWS co-infected with PCV-2, PRRS, and H. parasuis in Korea.
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KEYWORD
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